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Mertansine (CAS 139504-50-0) | ChemAbout

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StrongStructure SimilarSimilarity 0.91

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Similarity 0.89

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C₃₅H₄₈ClN₃O₁₀S

738.3 g/mol

APIDanger

Mertansine

CAS139504-50-0

Category

API

Compound Class

Natural Product

Primary Use

Pharmaceutical Raw Material

Mertansine, also known as DM1, is a thiol-containing maytansinoid used as a payload in antibody-drug conjugates (ADCs), where it is attached to a monoclonal antibody via a linker for targeted delivery.

pharmaceutical intermediate for ADC manufacturingresearch compound for targeted cancer therapy studies

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

Safety Reference

Corrosive

Toxic

Health Hazard

Danger

H300Fatal if swallowed

H310Fatal in contact with skin

H314

Identifiers

IUPAC Name

[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate

InChIKey

ANZJBCHSOXCCRQ-FKUXLPTCSA-N

SMILES

C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCS)C)\C)OC)(NC(=O)O2)O

Synonyms (13)

DM 1
DM1 [Maytansinoid]
Maytansinoid DM 1
Mertansine
Mertansine (DM1 Compound)
Mertansine (DM1)
Mertasine

Causes severe skin burns and eye damage

H340May cause genetic defects

H341Suspected of causing genetic defects

H350May cause cancer

H360May damage fertility or the unborn child

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure