Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate

Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate, commonly known as BOP, is a reagent widely used for the synthesis of amides from carboxylic acids and amines in peptide synthesis. It is prepared from 1-hydroxybenzotriazole and a chlorophosphonium reagent under basic conditions and offers advantages by minimizing side reactions such as dehydration of asparagine or glutamine residues.